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Homology Modeling of NAD(+)-Dependent DNA Ligase of the Wolbachia Endosymbiont of Brugia malayi and Its Drug Target Potential Using Dispiro-Cycloalkanones
Lymphatic filarial nematodes maintain a mutualistic relationship with the endosymbiont Wolbachia. Depletion of Wolbachia produces profound defects in nematode development, fertility, and viability and thus has great promise as a novel approach for treating filarial diseases. NAD(+)-dependent DNA lig...
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Udgivet i: | Antimicrob Agents Chemother |
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Main Authors: | , , , , , , |
Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
American Society for Microbiology
2015
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4468696/ https://ncbi.nlm.nih.gov/pubmed/25845868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03449-14 |
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