Homology Modeling of NAD(+)-Dependent DNA Ligase of the Wolbachia Endosymbiont of Brugia malayi and Its Drug Target Potential Using Dispiro-Cycloalkanones

Lymphatic filarial nematodes maintain a mutualistic relationship with the endosymbiont Wolbachia. Depletion of Wolbachia produces profound defects in nematode development, fertility, and viability and thus has great promise as a novel approach for treating filarial diseases. NAD(+)-dependent DNA lig...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Shrivastava, Nidhi, Nag, Jeetendra K., Pandey, Jyoti, Tripathi, Rama Pati, Shah, Priyanka, Siddiqi, Mohammad Imran, Misra-Bhattacharya, Shailja
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468696/
https://ncbi.nlm.nih.gov/pubmed/25845868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03449-14
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