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Molecular Characterization of an rsmD-Like rRNA Methyltransferase from the Wolbachia Endosymbiont of Brugia malayi and Antifilarial Activity of Specific Inhibitors of the Enzyme

The endosymbiotic organism Wolbachia is an attractive antifilarial drug target. Here we report on the cloning and expression of an rsmD-like rRNA methyltransferase from the Wolbachia endosymbiont of Brugia malayi, its molecular properties, and assays for specific inhibitors. The gene was found to be...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Rana, Ajay Kumar, Chandra, Sharat, Siddiqi, Mohammad Imran, Misra-Bhattacharya, Shailja
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2013
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719755/
https://ncbi.nlm.nih.gov/pubmed/23733469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02264-12
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