Increasing Prevalence of a Novel Triple-Mutant Dihydropteroate Synthase Genotype in Plasmodium falciparum in Western Kenya

The molecular basis of sulfadoxine-pyrimethamine (SP) resistance lies in a combination of single-nucleotide polymorphisms (SNPs) in two genes coding for Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and P. falciparum dihydropteroate synthase (Pfdhps), targeted by pyrimethamine and sulfadoxi...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Lucchi, Naomi W., Okoth, Sheila Akinyi, Komino, Franklin, Onyona, Philip, Goldman, Ira F., Ljolje, Dragan, Shi, Ya Ping, Barnwell, John W., Udhayakumar, Venkatachalam, Kariuki, Simon
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
Soggetti:
Epidemiology and Surveillance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468674/
https://ncbi.nlm.nih.gov/pubmed/25896703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04961-14
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