Characterization of Thrombin-Bound Dabigatran Effects on Protease-Activated Receptor-1 Expression and Signaling In Vitro

Thrombin, the key effector protease of the coagulation cascade, drives fibrin deposition and activates human platelets through protease-activated receptor-1 (PAR1). These processes are critical to the progression of thrombotic diseases. Thrombin is the main target of anticoagulant therapy, and major...

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Bibliographic Details
Published in:Mol Pharmacol
Main Authors: Chen, Buxin, Soto, Antonio G., Coronel, Luisa J., Goss, Ashley, van Ryn, Joanne, Trejo, JoAnn
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468637/
https://ncbi.nlm.nih.gov/pubmed/25934730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.096446
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