Enterococcus faecalis Gelatinase Mediates Intestinal Permeability via Protease-Activated Receptor 2

Microbial protease-mediated disruption of the intestinal epithelium is a potential mechanism whereby a dysbiotic enteric microbiota can lead to disease. This mechanism was investigated using the colitogenic, protease-secreting enteric microbe Enterococcus faecalis. Caco-2 and T-84 epithelial cell mo...

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Pubblicato in:Infect Immun
Autori principali: Maharshak, Nitsan, Huh, Eun Young, Paiboonrungruang, Chorlada, Shanahan, Michael, Thurlow, Lance, Herzog, Jeremy, Djukic, Zorka, Orlando, Roy, Pawlinski, Rafal, Ellermann, Melissa, Borst, Luke, Patel, Siten, Dotan, Iris, Sartor, Ryan B., Carroll, Ian M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
Soggetti:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468563/
https://ncbi.nlm.nih.gov/pubmed/25916983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00425-15
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