Immunogenic Display of Purified Chemically Cross-Linked HIV-1 Spikes

HIV-1 envelope glycoprotein (Env) spikes are prime vaccine candidates, at least in principle, but suffer from instability, molecular heterogeneity and a low copy number on virions. We anticipated that chemical cross-linking of HIV-1 would allow purification and molecular characterization of trimeric...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Leaman, Daniel P., Lee, Jeong Hyun, Ward, Andrew B., Zwick, Michael B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2015
Konular:
Vaccines and Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468504/
https://ncbi.nlm.nih.gov/pubmed/25878116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03738-14
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