TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis

Truncating mutations in the tumor suppressor gene adenomatous polyposis coli (APC) are the initiating step in the vast majority of sporadic colorectal cancers, and they underlie familial adenomatous polyposis (FAP) syndromes. Modeling of APC- driven tumor formation in the mouse has contributed subst...

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Detalhes bibliográficos
Publicado no:Oncoscience
Main Authors: Van Nieuwenhuysen, Tom, Naert, Thomas, Tran, Hong Thi, Van Imschoot, Griet, Geurs, Sarah, Sanders, Ellen, Creytens, David, Van Roy, Frans, Vleminckx, Kris
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468341/
https://ncbi.nlm.nih.gov/pubmed/26097888
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