TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis

Truncating mutations in the tumor suppressor gene adenomatous polyposis coli (APC) are the initiating step in the vast majority of sporadic colorectal cancers, and they underlie familial adenomatous polyposis (FAP) syndromes. Modeling of APC- driven tumor formation in the mouse has contributed subst...

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Dades bibliogràfiques
Publicat a:Oncoscience
Autors principals: Van Nieuwenhuysen, Tom, Naert, Thomas, Tran, Hong Thi, Van Imschoot, Griet, Geurs, Sarah, Sanders, Ellen, Creytens, David, Van Roy, Frans, Vleminckx, Kris
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468341/
https://ncbi.nlm.nih.gov/pubmed/26097888
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