mTOR pathway activation in multiple myeloma cell lines and primary tumour cells: pomalidomide enhances cytoplasmic-nuclear shuttling of mTOR protein

mTOR is a protein kinase that plays a central role in regulating critical cellular processes. We evaluated the activation and cellular localization of the mTOR pathway in multiple myeloma (MM) and analyzed the role of pomalidomide in regulating mTOR. By immunohistochemistry cytoplasmic p-mTOR staine...

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Publicat a:Oncoscience
Autors principals: Guglielmelli, Tommasina, Giugliano, Emilia, Brunetto, Vanessa, Rapa, Ida, Cappia, Susanna, Giorcelli, Jessica, Rrodhe, Sokol, Papotti, Mauro, Saglio, Giuseppe
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468324/
https://ncbi.nlm.nih.gov/pubmed/26097872
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