Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection

HLA class I polymorphism has a major influence on adult HIV disease progression. An important mechanism mediating this effect is the impact on viral replicative capacity (VRC) of the escape mutations selected in response to HLA-restricted CD8+ T-cell responses. Factors that contribute to slow progre...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Adland, Emily, Paioni, Paolo, Thobakgale, Christina, Laker, Leana, Mori, Luisa, Muenchhoff, Maximilian, Csala, Anna, Clapson, Margaret, Flynn, Jacquie, Novelli, Vas, Hurst, Jacob, Naidoo, Vanessa, Shapiro, Roger, Huang, Kuan-Hsiang Gary, Frater, John, Prendergast, Andrew, Prado, Julia G., Ndung’u, Thumbi, Walker, Bruce D., Carrington, Mary, Jooste, Pieter, Goulder, Philip J. R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468173/
https://ncbi.nlm.nih.gov/pubmed/26076345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004954
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