DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity

Retroviral integrases (INs) catalyse the integration of the reverse transcribed viral DNA into the host cell genome. This process is selective, and chromatin has been proposed to be a major factor regulating this step in the viral life cycle. However, the precise underlying mechanisms are still unde...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Naughtin, Monica, Haftek-Terreau, Zofia, Xavier, Johan, Meyer, Sam, Silvain, Maud, Jaszczyszyn, Yan, Levy, Nicolas, Miele, Vincent, Benleulmi, Mohamed Salah, Ruff, Marc, Parissi, Vincent, Vaillant, Cédric, Lavigne, Marc
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468133/
https://ncbi.nlm.nih.gov/pubmed/26075397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129427
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