Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent

Female 129:Stat1-null mice (129S6/SvEvTac-Stat1(tm1Rds) homozygous) uniquely develop estrogen-receptor (ER)-positive mammary tumors. Herein we report that the mammary glands (MG) of these mice have altered growth and development with abnormal terminal end buds alongside defective branching morphogen...

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Udgivet i:PLoS One
Main Authors: Chen, Jane Q., Mori, Hidetoshi, Cardiff, Robert D., Trott, Josephine F., Hovey, Russell C., Hubbard, Neil E., Engelberg, Jesse A., Tepper, Clifford G., Willis, Brandon J., Khan, Imran H., Ravindran, Resmi K., Chan, Szeman R., Schreiber, Robert D., Borowsky, Alexander D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468083/
https://ncbi.nlm.nih.gov/pubmed/26075897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129895
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