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Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent

Female 129:Stat1-null mice (129S6/SvEvTac-Stat1(tm1Rds) homozygous) uniquely develop estrogen-receptor (ER)-positive mammary tumors. Herein we report that the mammary glands (MG) of these mice have altered growth and development with abnormal terminal end buds alongside defective branching morphogen...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chen, Jane Q., Mori, Hidetoshi, Cardiff, Robert D., Trott, Josephine F., Hovey, Russell C., Hubbard, Neil E., Engelberg, Jesse A., Tepper, Clifford G., Willis, Brandon J., Khan, Imran H., Ravindran, Resmi K., Chan, Szeman R., Schreiber, Robert D., Borowsky, Alexander D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468083/
https://ncbi.nlm.nih.gov/pubmed/26075897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129895
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