Adeno-Associated Virus Vector Mediated Delivery of the HBV Genome Induces Chronic Hepatitis B Virus Infection and Liver Fibrosis in Mice

Liver cirrhosis and hepatocellular carcinomas are major health problems of chronic hepatitis B virus (HBV) infection. To date, rare model has reproduced liver fibrosis associated with long-term HBV infection which in turn has hindered both the understanding of HBV biology and the development of new...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ye, Lei, Yu, Haisheng, Li, Chengwen, Hirsch, Matthew L., Zhang, Liguo, Samulski, R. Jude, Li, Wuping, Liu, Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468063/
https://ncbi.nlm.nih.gov/pubmed/26075890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130052
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