Targeted inhibition of the Shroom3–Rho kinase protein–protein interaction circumvents Nogo66 to promote axon outgrowth

BACKGROUND: Inhibitory molecules in the adult central nervous system, including NogoA, impede neural repair by blocking axon outgrowth. The actin-myosin regulatory protein Shroom3 directly interacts with Rho kinase and conveys axon outgrowth inhibitory signals from Nogo66, a C-terminal inhibitory do...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:BMC Neurosci
Egile Nagusiak: Dickson, Heather M, Wilbur, Amanda, Reinke, Ashley A, Young, Mathew A, Vojtek, Anne B
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467669/
https://ncbi.nlm.nih.gov/pubmed/26077244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-015-0171-5
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