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Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn(23) Iowa mutation
Mutations within the Aβ (amyloid β) peptide, especially those clustered at residues 21–23, are linked to early-onset AD (Alzheimer’s disease) and primarily associated with cerebral amyloid angiopathy. The Iowa variant, a substitution of an aspartic acid residue for asparagine at position 23 (D23N),...
Shranjeno v:
| izdano v: | Biochem J |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4467552/ https://ncbi.nlm.nih.gov/pubmed/24028142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20130652 |
| Oznake: |
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