Regulation of Nucleotide Metabolism by Mutant p53 Contributes to its Gain-of-Function Activities

Mutant p53 (mtp53) is an oncogene that drives cancer cell proliferation. Here we report that mtp53 associates with the promoters of numerous nucleotide metabolism genes (NMG). Mtp53 knockdown reduces NMG expression and substantially depletes nucleotide pools, which attenuates GTP dependent protein (...

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Pubblicato in:Nat Commun
Autori principali: Kollareddy, Madhusudhan, Dimitrova, Elizabeth, Vallabhaneni, Krishna C., Chan, Adriano, Le, Thuc, Chauhan, Krishna M., Carrero, Zunamys I., Ramakrishnan, Gopalakrishnan, Watabe, Kounosuke, Haupt, Ygal, Haupt, Sue, Pochampally, Radhika, Boss, Gerard R., Romero, Damian G., Radu, Caius G., Martinez, Luis A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467467/
https://ncbi.nlm.nih.gov/pubmed/26067754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8389
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