EBNA3C regulates p53 through induction of Aurora kinase B

In multicellular organisms p53 maintains genomic integrity through activation of DNA repair, and apoptosis. EBNA3C can down regulate p53 transcriptional activity. Aurora kinase (AK) B phosphorylates p53, which leads to degradation of p53. Aberrant expression of AK-B is a hallmark of numerous human c...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Jha, Hem C., Yang, Karren, El-Naccache, Darine W., Sun, Zhiguo, Robertson, Erle S.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467402/
https://ncbi.nlm.nih.gov/pubmed/25691063
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