Cell-specific expression of artificial microRNAs targeting essential genes exhibit potent antitumor effect on hepatocellular carcinoma cells

To achieve specific and potent antitumor effect of hepatocyte carcinoma cells, replication defective adenoviral vectors, namely rAd/AFP-amiRG, rAd/AFP-amiRE and rAd/AFP-amiRP, were constructed which were armed with artificial microRNAs (amiRs) targeting essential functional genes glyceraldehyde-3-ph...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Mao, Chenyu, Liu, Hao, Chen, Ping, Ye, Jingjia, Teng, Lisong, Jia, Zhenyu, Cao, Jiang
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2015
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467396/
https://ncbi.nlm.nih.gov/pubmed/25691059
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