Cell-specific expression of artificial microRNAs targeting essential genes exhibit potent antitumor effect on hepatocellular carcinoma cells

To achieve specific and potent antitumor effect of hepatocyte carcinoma cells, replication defective adenoviral vectors, namely rAd/AFP-amiRG, rAd/AFP-amiRE and rAd/AFP-amiRP, were constructed which were armed with artificial microRNAs (amiRs) targeting essential functional genes glyceraldehyde-3-ph...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Mao, Chenyu, Liu, Hao, Chen, Ping, Ye, Jingjia, Teng, Lisong, Jia, Zhenyu, Cao, Jiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467396/
https://ncbi.nlm.nih.gov/pubmed/25691059
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