Combination of carbon ion beam and gemcitabine causes irreparable DNA damage and death of radioresistant pancreatic cancer stem-like cells in vitro and in vivo

We try to elucidate whether a carbon ion beam alone or in combination with gemcitabine has advantages over X-ray in targeting putative pancreatic cancer stem-like cells (CSCs) in vitro and in vivo. Colony, spheroid formation and tumorigenicity assays confirmed that CD44+/ESA+ cells sorted from PANC1...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Sai, Sei, Wakai, Toshifumi, Vares, Guillaume, Yamada, Shigeru, Kamijo, Takehiko, Kamada, Tadashi, Shirai, Toshiyuki
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2015
Assuntos:
Research Perspective
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467384/
https://ncbi.nlm.nih.gov/pubmed/25849939
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