Induction of cellular prion protein (PrPc) under hypoxia inhibits apoptosis caused by TRAIL treatment

Hypoxia decreases cytotoxic responses to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein. Cellular prion protein (PrPc) is regulated by HIF-1α in neurons. We hypothesized that PrPc is involved in hypoxia-mediated resistance to TRAIL-induced apoptosis. We found that hypoxia in...

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Vydáno v:Oncotarget
Hlavní autoři: Park, Jin-Young, Jeong, Jae-Kyo, Lee, Ju-Hee, Moon, Ji-Hong, Kim, Sung-Wook, Lee, You-Jin, Park, Sang-Youel
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467153/
https://ncbi.nlm.nih.gov/pubmed/25742790
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