Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction

We have used an unbiased proteomic profiling strategy to identify new potential therapeutic targets in tumor-initiating cells (TICs), a.k.a., cancer stem cells (CSCs). Towards this end, the proteomes of mammospheres from two breast cancer cell lines were directly compared to attached monolayer cells...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lamb, Rebecca, Harrison, Hannah, Smith, Duncan L., Townsend, Paul A., Jackson, Thomas, Ozsvari, Bela, Martinez-Outschoorn, Ubaldo E., Pestell, Richard G., Howell, Anthony, Lisanti, Michael P., Sotgia, Federica
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
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Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467101/
https://ncbi.nlm.nih.gov/pubmed/25671304
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