Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction

We have used an unbiased proteomic profiling strategy to identify new potential therapeutic targets in tumor-initiating cells (TICs), a.k.a., cancer stem cells (CSCs). Towards this end, the proteomes of mammospheres from two breast cancer cell lines were directly compared to attached monolayer cells...

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Vydáno v:Oncotarget
Hlavní autoři: Lamb, Rebecca, Harrison, Hannah, Smith, Duncan L., Townsend, Paul A., Jackson, Thomas, Ozsvari, Bela, Martinez-Outschoorn, Ubaldo E., Pestell, Richard G., Howell, Anthony, Lisanti, Michael P., Sotgia, Federica
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
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Priority Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467101/
https://ncbi.nlm.nih.gov/pubmed/25671304
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