Metformin increases degradation of phospholamban via autophagy in cardiomyocytes

Phospholamban (PLN) is an effective inhibitor of the sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA). Here, we examined PLN stability and degradation in primary cultured mouse neonatal cardiomyocytes (CMNCs) and mouse hearts using immunoblotting, molecular imaging, and [(35)S]methionine pulse-cha...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Teng, Allen C. T., Miyake, Tetsuaki, Yokoe, Shunichi, Zhang, Liyong, Rezende, Luís Mário, Sharma, Parveen, MacLennan, David H., Liu, Peter P., Gramolini, Anthony O.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466728/
https://ncbi.nlm.nih.gov/pubmed/26040000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508815112
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