Gene–gene interactions between TGF-β/Smad3 signalling pathway polymorphisms affect susceptibility to knee osteoarthritis

OBJECTIVE: Transforming growth factor/Smad family member 3 (TGF)-β/Smad3 signalling is essential for maintaining articular cartilage. A relationship between the genetic variants of TGF-β itself, TGF-β signalling and binding molecules, and osteoarthritis (OA) has been reported. Although variants of c...

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Pubblicato in:BMJ Open
Autori principali: Su, Sui-Lung, Yang, Hsin-Yi, Lee, Herng-Sheng, Huang, Guo-Shu, Lee, Chian-Her, Liu, Wan-Shan, Wang, Chih-Chien, Peng, Yi-Jen, Lai, Ching-Huang, Chen, Ching-Yang, Lin, Chin, Pan, Yu-Ting, Salter, Donald M, Chen, Hsiang-Cheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2015
Soggetti:
Rheumatology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466616/
https://ncbi.nlm.nih.gov/pubmed/26068512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2015-007931
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