Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme.

Cdk-interacting protein 1 (Cip1) is a p53-regulated 21-kDa protein that inhibits several members of the cyclin-dependent kinase (CDK) family. It was initially observed in complexes containing CDK4, cyclin D, and proliferating cell nuclear antigen (PCNA). PCNA, in conjunction with activator 1, acts a...

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Detalhes bibliográficos
Main Authors: Flores-Rozas, H, Kelman, Z, Dean, F B, Pan, Z Q, Harper, J W, Elledge, S J, O'Donnell, M, Hurwitz, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC44665/
https://ncbi.nlm.nih.gov/pubmed/7915843
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