Zinc-α2-Glycoprotein Modulates AKT-Dependent Insulin Signaling in Human Adipocytes by Activation of the PP2A Phosphatase

OBJECTIVE: Evidence from mouse models suggests that zinc-α2-glycoprotein (ZAG) is a novel anti-obesity adipokine. In humans, however, data are controversial and its physiological role in adipose tissue (AT) remains unknown. Here we explored the molecular mechanisms by which ZAG regulates carbohydrat...

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Udgivet i:PLoS One
Main Authors: Ceperuelo-Mallafré, Victòria, Ejarque, Miriam, Duran, Xavier, Pachón, Gisela, Vázquez-Carballo, Ana, Roche, Kelly, Núñez-Roa, Catalina, Garrido-Sánchez, Lourdes, Tinahones, Francisco J., Vendrell, Joan, Fernández-Veledo, Sonia
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465909/
https://ncbi.nlm.nih.gov/pubmed/26068931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129644
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