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Therapeutic Restoration of Spinal Inhibition via Druggable Enhancement of Potassium-Chloride Cotransporter KCC2–Mediated Chloride Extrusion in Peripheral Neuropathic Pain

Peripheral neuropathic pain, typified by the development of spontaneous pain or pain hypersensitivity following injury to the peripheral nervous system, is common, greatly impairs quality of life, and is inadequately treated with available drugs. Maladaptive changes in chloride homeostasis due to a...

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Dades bibliogràfiques
Publicat a:JAMA Neurol
Autors principals: Kahle, Kristopher T., Khanna, Arjun, Clapham, David E., Woolf, Clifford J.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465580/
https://ncbi.nlm.nih.gov/pubmed/24615367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2014.21
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