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Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA
Using a G-quadruplex bait, we identified the transcription co-activator Sub1 as a G-quadruplex binding protein by quantitative LC-MS/MS and demonstrated in vivo G-quadruplex binding by ChIP. In vitro, Sub1, and its human homolog PC4, bind preferentially to G-quadruplexes. This provides a possible me...
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| Publicado no: | Chem Commun (Camb) |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4465349/ https://ncbi.nlm.nih.gov/pubmed/25813861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cc00742a |
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