Limited Efficacy of α-Conopeptides, Vc1.1 and RgIA, To Inhibit Sensory Neuron Ca(V) Current1,2,3

Chronic pain is very difficult to treat. Thus, novel analgesics are a critical area of research. Strong preclinical evidence supports the analgesic effects of α-conopeptides, Vc1.1 and RgIA, which block α9α10 nicotinic acetylcholine receptors (nAChRs). However, the analgesic mechanism is controversi...

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Publicat a:eNeuro
Autors principals: Wright, Andrew B., Norimatsu, Yohei, McIntosh, J. Michael, Elmslie, Keith S.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2015
Matèries:
Failure to Replicate
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465272/
https://ncbi.nlm.nih.gov/pubmed/26078999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0057-14.2015
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