Overexpression of GRK6 rescues L-DOPA-induced signaling abnormalities in the dopamine-depleted striatum of hemiparkinsonian rats

L-DOPA therapy in Parkinson’s disease often results in side effects such as L-DOPA-induced dyskinesia (LID). Our previous studies demonstrated that defective desensitization of dopamine receptors caused by decreased expression of G protein-coupled receptor kinases (GRKs) plays a role. Overexpression...

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Veröffentlicht in:Exp Neurol
Hauptverfasser: Ahmed, M. Rafiuddin, Bychkov, Evgeny, Kook, Seunghyi, Zurkovsky, Lilia, Dalby, Kevin N., Gurevich, Eugenia V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4464750/
https://ncbi.nlm.nih.gov/pubmed/25687550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2015.02.008
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