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Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity in mice
A subset of patients with Parkinson’s disease acquires a debilitating dementia characterized by severe cognitive impairments (i.e. Parkinson’s disease dementia; PDD). Brains from PDD patients show extensive cholinergic loss as well as dopamine (DA) depletion. We used a mutant mouse model to directly...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Company of Biologists Limited
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3529349/ https://ncbi.nlm.nih.gov/pubmed/22864020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.010363 |
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