Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity in mice

A subset of patients with Parkinson’s disease acquires a debilitating dementia characterized by severe cognitive impairments (i.e. Parkinson’s disease dementia; PDD). Brains from PDD patients show extensive cholinergic loss as well as dopamine (DA) depletion. We used a mutant mouse model to directly...

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Bibliographic Details
Main Authors: Zurkovsky, Lilia, Bychkov, Evgeny, Tsakem, Elviche L., Siedlecki, Carley, Blakely, Randy D., Gurevich, Eugenia V.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Limited 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529349/
https://ncbi.nlm.nih.gov/pubmed/22864020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.010363
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