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Split-alignment of genomes finds orthologies more accurately

We present a new pair-wise genome alignment method, based on a simple concept of finding an optimal set of local alignments. It gains accuracy by not masking repeats, and by using a statistical model to quantify the (un)ambiguity of each alignment part. Compared to previous animal genome alignments,...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Frith, Martin C, Kawaguchi, Risa
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4464727/
https://ncbi.nlm.nih.gov/pubmed/25994148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0670-9
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