Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment

BACKGROUND: Interindividual epigenetic variation that occurs systemically must be established prior to gastrulation in the very early embryo and, because it is systemic, can be assessed in easily biopsiable tissues. We employ two independent genome-wide approaches to search for such variants. RESULT...

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Veröffentlicht in:Genome Biol
Hauptverfasser: Silver, Matt J, Kessler, Noah J, Hennig, Branwen J, Dominguez-Salas, Paula, Laritsky, Eleonora, Baker, Maria S, Coarfa, Cristian, Hernandez-Vargas, Hector, Castelino, Jovita M, Routledge, Michael N, Gong, Yun Yun, Herceg, Zdenko, Lee, Yong Sun, Lee, Kwanbok, Moore, Sophie E, Fulford, Anthony J, Prentice, Andrew M, Waterland, Robert A
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4464629/
https://ncbi.nlm.nih.gov/pubmed/26062908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0660-y
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