Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment

BACKGROUND: Interindividual epigenetic variation that occurs systemically must be established prior to gastrulation in the very early embryo and, because it is systemic, can be assessed in easily biopsiable tissues. We employ two independent genome-wide approaches to search for such variants. RESULT...

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Библиографические подробности
Опубликовано в: :Genome Biol
Главные авторы: Silver, Matt J, Kessler, Noah J, Hennig, Branwen J, Dominguez-Salas, Paula, Laritsky, Eleonora, Baker, Maria S, Coarfa, Cristian, Hernandez-Vargas, Hector, Castelino, Jovita M, Routledge, Michael N, Gong, Yun Yun, Herceg, Zdenko, Lee, Yong Sun, Lee, Kwanbok, Moore, Sophie E, Fulford, Anthony J, Prentice, Andrew M, Waterland, Robert A
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2015
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4464629/
https://ncbi.nlm.nih.gov/pubmed/26062908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0660-y
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