Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment

BACKGROUND: Interindividual epigenetic variation that occurs systemically must be established prior to gastrulation in the very early embryo and, because it is systemic, can be assessed in easily biopsiable tissues. We employ two independent genome-wide approaches to search for such variants. RESULT...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Silver, Matt J, Kessler, Noah J, Hennig, Branwen J, Dominguez-Salas, Paula, Laritsky, Eleonora, Baker, Maria S, Coarfa, Cristian, Hernandez-Vargas, Hector, Castelino, Jovita M, Routledge, Michael N, Gong, Yun Yun, Herceg, Zdenko, Lee, Yong Sun, Lee, Kwanbok, Moore, Sophie E, Fulford, Anthony J, Prentice, Andrew M, Waterland, Robert A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4464629/
https://ncbi.nlm.nih.gov/pubmed/26062908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0660-y
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