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The HRDC domain of E. coli RecQ helicase controls single-stranded DNA translocation and double-stranded DNA unwinding rates without affecting mechanoenzymatic coupling

DNA-restructuring activities of RecQ-family helicases play key roles in genome maintenance. These activities, driven by two tandem RecA-like core domains, are thought to be controlled by accessory DNA-binding elements including the helicase-and-RnaseD-C-terminal (HRDC) domain. The HRDC domain of hum...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Harami, Gábor M., Nagy, Nikolett T., Martina, Máté, Neuman, Keir C., Kovács, Mihály
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4464074/
https://ncbi.nlm.nih.gov/pubmed/26067769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11091
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