Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity.

Growth factor-triggered activation of Ras proteins is believed to be mediated by guanine nucleotide exchange factors (CDC25/GRF and SOS1/2) that promote formation of the active Ras GTP-bound state. Although the mechanism(s) of guanine nucleotide exchange factor regulation is unclear, recent studies...

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Autors principals: Quilliam, L A, Huff, S Y, Rabun, K M, Wei, W, Park, W, Broek, D, Der, C J
Format: Artigo
Idioma:Inglês
Publicat: 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC44636/
https://ncbi.nlm.nih.gov/pubmed/8078913
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