Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

The small GTPase Rac1 regulates various cellular processes, including cell migration. However, Rac1 can have opposing migratory effects. Here the authors show that two guanine nucleotide exchange factors, Tiam1 and P-Rex1, differentially regulate the Rac1 interactome to determine the downstream phen...

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מידע ביבליוגרפי

Principais autores:	Hadir Marei, Alejandro Carpy, Anna Woroniuk, Claire Vennin, Gavin White, Paul Timpson, Boris Macek, Angeliki Malliri
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Nature Portfolio 2016-02-01
סדרה:	Nature Communications
גישה מקוונת:	https://doi.org/10.1038/ncomms10664
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