Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways

Target of rapamycin is a Ser/Thr kinase that operates in two conserved multiprotein complexes, TORC1 and TORC2. Unlike TORC1, TORC2 is insensitive to rapamycin, and its functional characterization is less advanced. Previous genetic studies demonstrated that TORC2 depletion leads to loss of actin pol...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Rispal, Delphine, Eltschinger, Sandra, Stahl, Michael, Vaga, Stefania, Bodenmiller, Bernd, Abraham, Yann, Filipuzzi, Ireos, Movva, N. Rao, Aebersold, Ruedi, Helliwell, Stephen B., Loewith, Robbie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463442/
https://ncbi.nlm.nih.gov/pubmed/25882841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.627794
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