Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways

Target of rapamycin is a Ser/Thr kinase that operates in two conserved multiprotein complexes, TORC1 and TORC2. Unlike TORC1, TORC2 is insensitive to rapamycin, and its functional characterization is less advanced. Previous genetic studies demonstrated that TORC2 depletion leads to loss of actin pol...

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Vydáno v:J Biol Chem
Hlavní autoři: Rispal, Delphine, Eltschinger, Sandra, Stahl, Michael, Vaga, Stefania, Bodenmiller, Bernd, Abraham, Yann, Filipuzzi, Ireos, Movva, N. Rao, Aebersold, Ruedi, Helliwell, Stephen B., Loewith, Robbie
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463442/
https://ncbi.nlm.nih.gov/pubmed/25882841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.627794
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