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Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

Tau amyloid assemblies propagate aggregation from the outside to the inside of a cell, which may mediate progression of the tauopathies. The critical size of Tau assemblies, or “seeds,” responsible for this activity is currently unknown, but this could be important for the design of effective therap...

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Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: Mirbaha, Hilda, Holmes, Brandon B., Sanders, David W., Bieschke, Jan, Diamond, Marc I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463437/
https://ncbi.nlm.nih.gov/pubmed/25887395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.652693
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