Endoglin Regulation of Smad2 Function Mediates Beclin1 Expression and Endothelial Autophagy

Autophagy is the targeted degradation of proteins and organelles critical for homeostasis and cell survival. Transforming growth factor β (TGF-β) differentially regulates autophagy in a context-specific manner, although the precise intracellular mechanisms remain less clear. Importantly, how TGF-β c...

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Udgivet i:J Biol Chem
Main Authors: Pan, Christopher C., Kumar, Sanjay, Shah, Nirav, Bloodworth, Jeffrey C., Hawinkels, Lukas J. A. C., Mythreye, Karthikeyan, Hoyt, Dale G., Lee, Nam Y.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463436/
https://ncbi.nlm.nih.gov/pubmed/25931117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.630178
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