IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-κB signaling

Osteosarcoma is a common malignant bone tumor with a propensity to metastasize to the lungs. Epigenetic abnormalities have been demonstrated to underlie osteosarcoma development; however, the epigenetic mechanisms that are involved in metastasis are not yet clear. Here, we analyzed 2 syngeneic prima...

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Udgivet i:J Clin Invest
Main Authors: Lu, Jinchang, Song, Guohui, Tang, Qinglian, Zou, Changye, Han, Feng, Zhao, Zhiqiang, Yong, Bicheng, Yin, Junqiang, Xu, Huaiyuan, Xie, Xianbiao, Kang, Tiebang, Lam, YingLee, Yang, Huiling, Shen, Jingnan, Wang, Jin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463198/
https://ncbi.nlm.nih.gov/pubmed/25822025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78437
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