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Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

Islet amyloid polypeptide (IAPP) is the constituent peptide of amyloid deposits found in the islets of non-insulin-dependent diabetic patients. Formation of islet amyloid is associated with a progressive destruction of insulin-producing beta cells. Factors responsible for the conversion of IAPP into...

Celý popis

Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: de Koning, E J, Morris, E R, Hofhuis, F M, Posthuma, G, Höppener, J W, Morris, J F, Capel, P J, Clark, A, Verbeek, J S
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1994
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44627/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8078905/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.18.8467
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