Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

Islet amyloid polypeptide (IAPP) is the constituent peptide of amyloid deposits found in the islets of non-insulin-dependent diabetic patients. Formation of islet amyloid is associated with a progressive destruction of insulin-producing beta cells. Factors responsible for the conversion of IAPP into...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	de Koning, E J, Morris, E R, Hofhuis, F M, Posthuma, G, Höppener, J W, Morris, J F, Capel, P J, Clark, A, Verbeek, J S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44627/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8078905/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.18.8467
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