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MnSOD Overexpression Reduces Fibrosis and Pro-Apoptotic Signaling in the Aging Mouse Heart

Contractility of the heart is impaired with advancing age via mechanical remodeling, as myocytes are lost through apoptosis and collagenous fibers accumulate. Exercise training confers protection against fibrosis and apoptosis in the aging heart, but the mechanisms remain poorly understood. We recen...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Gerontol A Biol Sci Med Sci
Hauptverfasser: Kwak, Hyo-Bum, Lee, Yang, Kim, Jong-Hee, Van Remmen, Holly, Richardson, Arlan G., Lawler, John M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462657/
https://ncbi.nlm.nih.gov/pubmed/25016531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glu090
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