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Enzymatic Basis of ‘Hybridity’ in Thiomarinol Biosynthesis

Thiomarinol is a naturally occurring double-headed antibiotic that is highly potent against methicillin-resistant Staphylococcus aureus. Its structure comprises two antimicrobial sub-components, marinolic acid and holothin, linked by an amide bond. TmlU was thought to be the sole enzyme responsible...

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Foilsithe in:Angew Chem Int Ed Engl
Main Authors: Dunn, Zachary D., Wever, Walter J., Economou, Nicoleta J., Bowers, Albert A., Li, Bo
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462198/
https://ncbi.nlm.nih.gov/pubmed/25726835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201411667
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