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Enzymatic Basis of ‘Hybridity’ in Thiomarinol Biosynthesis
Thiomarinol is a naturally occurring double-headed antibiotic that is highly potent against methicillin-resistant Staphylococcus aureus. Its structure comprises two antimicrobial sub-components, marinolic acid and holothin, linked by an amide bond. TmlU was thought to be the sole enzyme responsible...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4462198/ https://ncbi.nlm.nih.gov/pubmed/25726835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201411667 |
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