Production of monoclonal antibodies against GPCR using cell-free synthesized GPCR antigen and biotinylated liposome-based interaction assay

G-protein-coupled receptors (GPCRs) are one of the most important drug targets, and anti-GPCR monoclonal antibody (mAb) is an essential tool for functional analysis of GPCRs. However, it is very difficult to develop GPCR-specific mAbs due to difficulties in production of recombinant GPCR antigens, a...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Takeda, Hiroyuki, Ogasawara, Tomio, Ozawa, Tatsuhiko, Muraguchi, Atsushi, Jih, Pei-Ju, Morishita, Ryo, Uchigashima, Motokazu, Watanabe, Masahiko, Fujimoto, Toyoshi, Iwasaki, Takahiro, Endo, Yaeta, Sawasaki, Tatsuya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462149/
https://ncbi.nlm.nih.gov/pubmed/26061673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11333
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